The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies reviews scientific findings and stakeholders concerns related to the safety of the recommended childhood immunization schedule. This report also identifies potential research approaches, methodologies and study designs that could inform this question, considering strengths, weaknesses as well as ethical and financial feasibility of each approach. This report draws on data from existing surveillance systems, such as the Vaccine Safety Datalink, could be used and offers the best means for ongoing research efforts regarding the safety of the schedule. In recognition of this, future federal research approaches should: collect and assess evidence regarding public confidence in and concerns about the entire childhood immunization schedule, with the goal to improve communication with health care professionals, and between health care professionals and the public regarding safety; standardize definitions of key elements of the schedule, and relevant health outcomes; establish research priorities on the basis of epidemiological evidence, biological plausibility, and feasibility; and continue to fund and support the Vaccine Safety Datalink project to study the safety of the recommended immunization schedule.
